Breast cancer Recommended dose: 300 mg/m
2 via IV infusion over 3 hr every 3 wk. Premed: Administer approx 30 min prior to Paxus PM. Hydrocortisone 100 mg IV, pheniramine maleate 45.5 mg IV & cimetidine or ranitidine 300 mg or ranitidine 50 mg IV.
Patient w/ febrile & severe neutropenia (<500 cells/mm3), thrombocytopenia (<50,000 cells/mm3) or grade 3 neurological toxicities Dose reduction to 240 mg/m
2, may be further reduced to 190 mg/m
2.
NSCLC Initially 230 mg/m
2 via IV infusion over 3 hr, followed by cisplatin 60 mg/m
2 every 3 wk. Premed: Administer approx 30 min prior to Paxus PM. Hydrocortisone 100 mg IV, pheniramine maleate 45.5 mg IV, cimetidine 300 mg or ranitidine 50 mg IV. Ondansetron 8 mg IV may be administered as prophylactic anti-emetic prior to cisplatin administration.
Patient w/ febrile & severe neutropenia (<500 cells/mm3), thrombocytopenia (<50,000 cells/mm3) for >1 wk or grade 2 neurological, hepatic, other non-hematological toxicities Reduce dose to 185 mg/m
2, may be further reduced to 145 mg/m
2.
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